American Airlines flight AA 5378: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 13:59 Chicago O'Hare (ORD) 3 16:33 Knoxville (TYS)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective 2025-06-05 through 2025-07-04
Daily 13:59 Chicago O'Hare (ORD) 3 16:38 Knoxville (TYS)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2025-07-05 through 2025-09-02
Daily 17:04 Huntsville (HSV) 19:40 Charlotte (CLT)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:36 Effective 2025-09-03 through 2025-10-05
Daily 17:05 Huntsville (HSV) 19:40 Charlotte (CLT)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:35 Effective 2025-10-06 through 2025-11-01
Daily 20:30 Charlotte (CLT) 22:20 Fort Wayne (FWA)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:50 Effective 2025-05-05 through 2025-06-04
Wed,Thu,Sat 20:56 Charlotte (CLT) 22:06 Charleston (CHS)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:10 Valid until 2025-05-03
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This flight number is listed as serving the following routes:
American Airlines flight AA 5378: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:

American Airlines AA5378
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)

American Airlines AA5378
Effective 2025-07-05 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

American Airlines AA5378
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:36, non-stop
Canadair CRJ 900 (CR9)

American Airlines AA5378
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:35, non-stop
Canadair CRJ 900 (CR9)

American Airlines AA5378
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Canadair CRJ 900 (CR9)

American Airlines AA5378
Valid until 2025-05-03
Mon
-
Tue
-
Wed
Thu
Fri
-
Sat
Sun
-
Duration: 1:10, non-stop
Canadair CRJ 900 (CR9)
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This flight number is listed as serving the following routes:
  • Charlotte (CLT) - Charleston (CHS)
  • Charlotte (CLT) - Fort Wayne (FWA)
  • Chicago O'Hare (ORD) - Knoxville (TYS)
  • Huntsville (HSV) - Charlotte (CLT)