American Airlines flight AA 4425: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Mon,Tue,Thu,Fri,Sun 08:09 Chicago O'Hare (ORD) 3 10:29 Indianapolis (IND)
AA 4425 Non-stop Embraer EMB 175 (E75) 1:20 Valid until 2026-01-05
Daily 08:20 Ronald Reagan Washington (DCA) 2 11:22 Key West (EYW)
AA 4425 Non-stop Embraer EMB 175 (E75) 3:02 Effective 2026-07-02 through 2026-08-04
Daily 09:40 Chicago O'Hare (ORD) 3 12:08 John Glenn Columbus (CMH)
AA 4425 Non-stop Embraer EMB 175 (E75) 1:28 Effective 2026-04-07 through 2026-05-20
Sat 09:48 Chicago O'Hare (ORD) 3 13:56 Sarasota/Bradenton (SRQ)
AA 4425 Non-stop Embraer EMB 175 (E75) 3:08 Effective 2026-03-14 through 2026-04-04
Sat 09:55 Raleigh/Durham (RDU) 2 11:34 New York LaGuardia (LGA) B
AA 4425 Non-stop Embraer EMB 175 (E75) 1:39 Effective 2026-01-10 through 2026-02-07
Mon-Fri,Sun 10:34 Raleigh/Durham (RDU) 2 12:13 New York LaGuardia (LGA) B
AA 4425 Non-stop Embraer EMB 175 (E75) 1:39 Effective 2026-01-06 through 2026-02-11
Mon-Fri 10:40 New York LaGuardia (LGA) B 12:35 Raleigh/Durham (RDU) 2
AA 4425 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2026-02-12 through 2026-03-06
Daily 10:43 Philadelphia (PHL) 12:06 Martha's Vineyard (MVY)
AA 4425 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-08-05 through 2026-09-08
Sat 10:45 Indianapolis (IND) 11:09 Chicago O'Hare (ORD) 3
AA 4425 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:24 Valid until 2026-01-03
Sun 10:52 New York LaGuardia (LGA) B 12:49 Raleigh/Durham (RDU) 2
AA 4425 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Effective 2026-02-15 through 2026-03-01
Mon,Tue,Thu,Fri,Sun 11:00 Indianapolis (IND) 11:24 Chicago O'Hare (ORD) 3
AA 4425 Non-stop Embraer EMB 175 (E75) 1:24 Valid until 2026-01-05
Daily 11:34 Key West (EYW) 14:24 Ronald Reagan Washington (DCA) 2
AA 4425 Non-stop Embraer EMB 175 (E75) 2:50 Effective 2026-07-02 through 2026-08-04
Daily 12:36 Martha's Vineyard (MVY) 14:05 Philadelphia (PHL)
AA 4425 Non-stop Embraer EMB 175 (E75) 1:29 Effective 2026-08-05 through 2026-09-08
Daily 12:40 New York LaGuardia (LGA) B 14:21 Raleigh/Durham (RDU) 2
AA 4425 Non-stop Embraer EMB 175 (E75) 1:41 Effective 2026-09-09 through 2026-10-04
Mon-Fri 13:05 Raleigh/Durham (RDU) 2 14:53 New York LaGuardia (LGA) B
AA 4425 Non-stop Embraer EMB 175 (E75) 1:48 Effective 2026-02-12 through 2026-03-06
Sun 13:19 Raleigh/Durham (RDU) 2 15:10 New York LaGuardia (LGA) B
AA 4425 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:51 Effective 2026-02-15 through 2026-03-01
Daily 13:46 John Glenn Columbus (CMH) 14:20 Chicago O'Hare (ORD) 3
AA 4425 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2026-04-07 through 2026-05-20
Sat 14:26 Sarasota/Bradenton (SRQ) 16:52 Chicago O'Hare (ORD) 3
AA 4425 Non-stop Embraer EMB 175 (E75) 3:26 Effective 2026-03-14 through 2026-04-04
Daily 14:51 Raleigh/Durham (RDU) 2 16:29 New York LaGuardia (LGA) B
AA 4425 Non-stop Embraer EMB 175 (E75) 1:38 Effective 2026-09-09 through 2026-10-04
Mon-Thu,Sun 18:15 New York LaGuardia (LGA) B 20:29 Columbia (CAE)
AA 4425 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:14 Effective 2026-03-08 through 2026-04-06
Daily 21:21 Ronald Reagan Washington (DCA) 2 23:07 Minneapolis/Saint Paul (MSP) 1
AA 4425 Non-stop Embraer EMB 175 (E75) 2:46 Effective from 2026-10-05
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4425: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4425
08:09
Chicago O'Hare (ORD) 3

10:29
Indianapolis (IND)
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:20, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
08:20
Ronald Reagan Washington (DCA) 2

11:22
Key West (EYW)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:02, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
09:40
Chicago O'Hare (ORD) 3

12:08
John Glenn Columbus (CMH)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:28, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
09:48
Chicago O'Hare (ORD) 3

13:56
Sarasota/Bradenton (SRQ)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:08, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
09:55
Raleigh/Durham (RDU) 2

11:34
New York LaGuardia (LGA) B
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
10:34
Raleigh/Durham (RDU) 2

12:13
New York LaGuardia (LGA) B
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
10:40
New York LaGuardia (LGA) B

12:35
Raleigh/Durham (RDU) 2
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
10:43
Philadelphia (PHL)

12:06
Martha's Vineyard (MVY)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
10:45
Indianapolis (IND)

11:09
Chicago O'Hare (ORD) 3
Valid until 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:24, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4425
10:52
New York LaGuardia (LGA) B

12:49
Raleigh/Durham (RDU) 2
Effective 2026-02-15 through 2026-03-01
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4425
11:00
Indianapolis (IND)

11:24
Chicago O'Hare (ORD) 3
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
11:34
Key West (EYW)

14:24
Ronald Reagan Washington (DCA) 2
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
12:36
Martha's Vineyard (MVY)

14:05
Philadelphia (PHL)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:29, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
12:40
New York LaGuardia (LGA) B

14:21
Raleigh/Durham (RDU) 2
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:41, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
13:05
Raleigh/Durham (RDU) 2

14:53
New York LaGuardia (LGA) B
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:48, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
13:19
Raleigh/Durham (RDU) 2

15:10
New York LaGuardia (LGA) B
Effective 2026-02-15 through 2026-03-01
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:51, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4425
13:46
John Glenn Columbus (CMH)

14:20
Chicago O'Hare (ORD) 3
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
14:26
Sarasota/Bradenton (SRQ)

16:52
Chicago O'Hare (ORD) 3
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:26, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
14:51
Raleigh/Durham (RDU) 2

16:29
New York LaGuardia (LGA) B
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4425
18:15
New York LaGuardia (LGA) B

20:29
Columbia (CAE)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
-
Sat
-
Sun
Duration: 2:14, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4425
21:21
Ronald Reagan Washington (DCA) 2

23:07
Minneapolis/Saint Paul (MSP) 1
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:46, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - Indianapolis (IND)
  • Chicago O'Hare (ORD) - John Glenn Columbus (CMH)
  • Chicago O'Hare (ORD) - Sarasota/Bradenton (SRQ)
  • Key West (EYW) - Ronald Reagan Washington (DCA)
  • New York LaGuardia (LGA) - Columbia (CAE)
  • New York LaGuardia (LGA) - Raleigh/Durham (RDU)
  • Philadelphia (PHL) - Martha's Vineyard (MVY)
  • Ronald Reagan Washington (DCA) - Minneapolis/Saint Paul (MSP)
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